反恐先鋒「美國賤隊」得知恐怖份子正進行一項毀滅世界的邪惡計畫後，徵召百老匯巨星蓋瑞強斯頓出使臥底任務。然而，恐怖行動的幕後黑手，也不是省油的燈，利用喬治庫隆尼、麥特戴蒙、西恩潘等好萊塢巨星，一步步將世界推向毀滅之路。《南方公園》製作群全力耍賤使壞，將反恐聖戰與流行文化惡搞串連，諷刺美國反恐戰的荒謬與神經質，以超越《ID4星際終結者》的驚人破壞力摧毀巴黎、開羅地標性建築，屠殺十餘位好萊塢名流，還有讓《色戒》和《第六感追緝令》都宛如小學生牽手般的超尺度勁爆床戲！

Team America learns that a power hungry dictator is brokering weapons of mass destruction to terrorists. To infiltrate the terrorist network, Team America recruits Gary Johnston, a rising star on Broadway to go undercover. Although initially reluctant to sacrifice his promising career, Gary realizes that his acting gift is needed for a higher cause.